CHOPping the biologics?!

Chopping off the chondrocyte proteome

The progressive nature of osteoarthritis is manifested by the dynamic increase of degenerated articular cartilage, which is one of the major characteristics of this debilitating disease. As articular chondrocytes become exposed to inflammatory stress they enter a pro-catabolic state, which leads to the secretion and activation of a plethora of proteases. In aim to detect the disease before mass...

Barrier Slicing and Chopping

One of the critiques on program slicing is that slices presented to the user are hard to understand. This is partly due to bad user interfaces, but mainly related to the problem that slicing ‘dumps’ the results onto the user without any explanation. This work will present an approach that can be used to ‘filter’ slices. This approach basically introduces ‘barriers’ which are not allowed to be p...

The Chopping Board: Real-time Sample Editor

Chopping and storing in one

Tmod points the way hen it comes to actin dynamics, the pointed end of the actin filament is the forgotten cousin. The barbed end is in a state of constant flux in motile cells, pushing out the front of the cell, whereas the pointed end rarely rates a mention. But now, Mardahl-Dumesnil and Fowler report that in the actin-containing thin filaments of developing fly muscles, which grow at a more ...

Chopping time of the FPU α-model

We study, both numerically and analytically, the time needed to observe the breaking of an FPU α-chain in two or more pieces, starting from an unbroken configuration at a given temperature. It is found that such a “chopping” time is given by a formula that, at low temperatures, is of the Arrhenius-Kramers form, so that the chain does not break up on an observable time-scale. The result explains...